The International MPS Symposium has a rich history that began in 1988 with the first (unofficial) gathering held in Minneapolis, Minnesota, organized by Dr. Chet Whitley. Initially conceived as a small meeting to bring together researchers, clinicians, and families affected by mucopolysaccharidoses (MPS), its purpose was to share knowledge, foster collaboration, and provide hope to families by advancing research and care. Over the decades, the symposium has grown into a premier global event held every two years, attracting participants from all over the world. Host locations rotate internationally to reflect the worldwide impact of MPS and engage diverse communities.

In its early years, the symposium focused primarily on clinical and scientific advancements in MPS research and treatments. Over time, it expanded to include patient and family support programs, educational workshops, and advocacy initiatives. This evolution allowed the symposium to serve not only as a platform for scientific breakthroughs but also as a place for uniting voices to address medical, emotional, and logistical challenges associated with MPS. The symposium has celebrated significant milestones, including progress in enzyme replacement therapies, gene therapy research, and newborn screening, all of which have been discussed and advanced during its sessions. These gatherings have been instrumental in fostering global collaborations and inspiring new directions in research and care. Families, patients, researchers, clinicians, and industry stakeholders now come together at each symposium to address disparities in healthcare and advocate for equitable access to cutting-edge treatments.

As the symposium has evolved, its themes have begun to focus on innovative solutions such as artificial intelligence and the future of diagnostics, treatment, and support. The upcoming 2026 International MPS Symposium in Florence, Italy, will highlight the advancements of the past two decades while envisioning the next 20 years of progress. This legacy of collaboration, inclusivity, and impact continues to make the International MPS Symposium a cornerstone of hope and knowledge for the global MPS community.